Leneva
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Leneva is a first-of-its-kind human adipose tissue for soft tissue reconstruction.
As an all-natural extracellular injectable matrix, Leneva is a safe, natural, off-the-shelf solution that has multiple clinical applications including, but not limited to:
• Diabetic Foot Ulcers
• Pressure Ulcers
• Tunneling Wounds
• Fat Pad Reconstruction Procedures
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Features and Benefits
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Ready to use out of packaging reducing procedural preparation time
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Wound treatment may allow for decreased long-term health costs from repeat patient visits due to wound recurrence
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Preservation of natural derived endogenous components (matrix proteins, growth factors, cytokines) vital to adipogenesis and angiogenesis
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Provides extracellular matrix that functions as a scaffold for patients own cells to create new fat
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Pre-clinical studies in athymic mice demonstrate significant adipocyte formation in the host
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Leneva is tested for sterility per USP<71> without the need for terminal sterilization methods
Clinical Use Examples
Leneva is injected where fat naturally exists to replace volume where fat loss occurs. This adipose tissue matrix allograft injection is commonly used to restore volume in high-pressure areas of the foot and other parts of the body. Leneva is intended for the replacement of damaged or inadequate integumental adipose tissue matrix. Clinical applications of Leneva include, but are not limited to, diabetic foot ulcers, pressure ulcers, tunneling wounds, and fat pad reconstruction procedures.
Leneva injection for treatment of soft tissue defects include:
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Acute Wounds
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Chronic Wounds
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Debridements
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Dehisced Wounds
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Diabetic Foot Ulcers (DFUs)
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Venous Leg Ulcers (VLUs)
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Pressure Ulcers (PUs)
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Friction Reduction
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Tissue Augmentation with Allograft Adipose Matrix
For the Diabetic Foot in Remission
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Day 1:
Initial Injection
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4 Weeks:
Post-Injection
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4 Months:
Post-Op.
Shahin et al. October, 16, 2017
Our Processing Preserves Native Growth Factors
Leneva passes strict standards for patient safety. With minimal processing, Leneva is tested for endotoxin and for sterility per
USP <71>, while preserving the key growth factors needed for adipogenesis and angiogenesis.
Leneva undergoes strict processing that’s designed to maintain its structural integrity without sacrificing quality and sterility.
This process allows for retention of key matrix proteins such as Collagen IV and Collagen VI as well as adipogenic and angiogenic factors leptin, adiponectin, FGF-2 and VEGF, while removing residual lipid, cellular fragments, and DNA content. As an all-natural treatment, Leneva provides the necessary scaffolding and biological components that utilize the body’s own fat cell regeneration process to produce natural results.1
Centurion's Stamp Of Approval
Leneva Adipose Tissue Matrix
As a global innovator, Centurion Therapeutics partners with MTF Biologics, and specializes in developing and delivering cutting-edge therapies that leverage the body's natural healing processes. With a commitment to patient safety and clinical excellence, Centurion ensures that all its products, including the Leneva Adipose Matrix injection, meet the highest standards of quality and efficacy. Their advanced matrix tissue technologies provide the necessary scaffolding and biological components to promote natural tissue regeneration. Through rigorous testing and adherence to stringent regulatory requirements, Centurion Therapeutics delivers reliable, effective solutions designed to enhance patient outcomes and improve quality of life.
Leneva Adipose Matrix Ordering and Service Information
Order No.
Description
Volume
UPC Code
WC5101
Leneva, Adipose Matrix 1.5cc
1.5cc
840045715756
WC5103
Leneva, Adipose Matrix 3cc
3cc
840045715763
Leneva FAQ
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What is Leneva Allograft Adipose Matrix?An FAQ section can bLeneva Allograft Adipose Matrix is comprised of adipose tissue which is intended for the replacement of damaged or inadequate integumental adipose tissue matrix in areas of the body where native fat would exist. Leneva Allograft Adipose Matrix may also be used for the reinforcement or supplemental support in underlying adipose tissue matrix as the result of damage or naturally occurring defects. The process utilized preserves the extracellular matrix of the allograft adipose. The resulting allograft serves as a framework to support the cellular repopulation and vascularization at the surgical site.e used to quickly answer common questions about your business like "Where do you ship to?", "What are your opening hours?", or "How can I book a service?".
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What are the indications for Leneva?As an HCT/P Leneva does not have specific indications. It is intended for homologous use and should be used for the replacement or augmentation of damaged or inadequate integumental adipose tissue.
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Is there clinical data on Leneva?The safety and remodeling over time of Leneva in human patients was shown in a clinical study, where no severe adverse events were reported and injected Leneva was completely remodeled into native fat by 6 months.3 This and other relevant published peer-reviewed clinical articles, as well as clinical case summaries, can be provided by request to by your Wound Care Consultant.
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What types of wounds can Leneva be used on?Leneva can be used anywhere on the body where adipose tissue naturally occurs.
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What is the FDA regulatory status for Leneva?Leneva is regulated as a human cell/tissue product (H/CTP) under 21 CFR Part 1271 and Section 361 of the Public Health Services Act. FDA registration listing can be found on the company website mtfbiologics.org or can be provided upon request.
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Should I offload after injecting Leneva?Offloading is recommended after injecting Leneva. Patients are commonly offloaded for two to four weeks. Use preferred offloading method based on your clinical discretion.